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What Is C4 Deficiency?


A deficiency in complement C4 levels has been linked to different forms of kidney disease and chronic hepatitis. It has also been found in a number of childhood diseases, including: Henoch-Schonlein purpura, a type of inflammation of the blood vessels.

What does a high C4 blood test mean?

Complement C4 is a protein that is important for your immune function. It helps clear infections and protects against autoimmunity. Low levels may point to autoimmune disease, including lupus. High levels are rare, poorly understood, and may signal inflammation.

What is normal C4 level?

Normal Results Normal ranges for C4 is 15 to 45 milligrams per deciliter (mg/dL) (0.15 to 0.45 g/L).

What is the meaning of C3 and C4?

C3 and C4 are the most commonly measured complement components. When the complement system is turned on during inflammation, levels of complement proteins may go down. For example, people with active lupus erythematosus may have lower-than-normal levels of the complement proteins C3 and C4.

What does a low C4 blood test mean?

A low level of C4 is associated with autoimmune diseases, such as lupus and rheumatoid arthritis. The complement C4 test only requires basic preparation and carries few risks. The sample of your blood will be sent to a laboratory for analysis. The results will then be sent to your doctor.

What kills lupus patients?

Because it can lead to cardiovascular disease, lupus can kill women in their 20s by causing heart attacks and strokes, Gilkeson said. People with lupus also can die at young ages due to infections that are related to the immune-suppressing drugs taken to control the disease.

What causes elevated C4A levels?

C4A levels can be increased in people with Lyme disease, Chronic Inflammatory Response Syndrome (CIRS), or Mold Illness.

What is a C3 and C4 blood test for?

Complement tests, most commonly C3 and C4, are used to determine whether deficiencies or abnormalities in the complement system are causing, or contributing to, a person’s disease or condition. Total complement activity (CH50) may be ordered to look at the integrity of the entire classical complement pathway.


What causes elevated C3 and C4?

It seems that elevated C3 and C4 are likely to result of increased synthesis in the liver in response to cytokines e.g. IL-1β, IL-6 or tumor necrosis factor (TNF), which are increased in active CU and are known to control synthesis of the APR proteins [9].

What is C4 supplement used for?

C4 Energy promotes endurance, hydration and heightened physical performance. Every can contains the patented, clinically studied CarnoSyn®, which can help to fight fatigue and improve muscular endurance.

What are normal C3 and C4 levels?

The University Reference Laboratories normal range for C3 is 80–178 mg/dl, for C4 is 12–42 mg/dl, for CRP is 0.0–3.0 mg/l, and for ESR is 0–14 mm/h for males under 50 years old, 0–19 mm/h for females under 50 years old, 0–19 for males between 50 and 80 years old, and 0–29 mm/h for females between 50 and 80 years old.

What do low levels of C3 and C4 mean?

Low levels of C3 associated with low levels of C4 demonstrate classical pathway activation and strongly suggest immune complex disease. They are found most commonly in cases of active SLE.

What are the difference between C3 and C4 plants?

C3 plants use the C3 pathway or Calvin cycle for the dark reaction of photosynthesis. C4 plants use the C4 pathway or Hatch-Slack Pathway for the dark reaction of photosynthesis. These plants are cool-season plants, commonly found in cool and wet areas. These plants are warm-season plants, commonly found in dry areas.

What is an example of a C4 plant?

Examples of C4 plants include corn, sorghum, sugarcane, millet, and switchgrass. By contrast, with their adaptations, C4 plants are not as limited by carbon dioxide, and under elevated carbon dioxide levels, the growth of C4 plants did not increase as much as C3 plants.

Why are C4 plants better than C3?

C4 plants are more efficient than C3 due to their high rate of photosynthesis and reduced rate of photorespiration. In C4 plants, photorespiration is highly reduced because carbon dioxide concentration is high at the RuBisCO site.

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